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The FLARE Study

Flarin Patient Information Leaflets

The FLARE study: ‘A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen’

The FLARE study objective was to investigate the short-term efficacy and safety of Flarin novel lipid ibuprofen formulation (1200 mg / day soft gel sapsules) compared with standard liquid filled ibuprofen capsules (1200 mg / day or 2400 mg / day) in patients with episodic knee arthralgia/flaring knee pain.

The Flare study recruited 462 primary care patients and all patients received treatment for 5 days with the option to continue for an additional 5 days.

The study met its primary endpoint and demonstrated that Flarin lipid formulated  (1200 mg / day) was non-inferior to standard ibuprofen liquid filled capsules (2400  mg / day) in relieving flaring knee pain.

The most commonly reported adverse events were GI disorders, a known ibuprofen adverse effect with 24 ( 16.2%) patients reporting these in the Flarin (1200mg/day)treated group compared to 35 (22.6%) and 45 (28.3%) of patients in the 1200mg/day and 2400mg/day standard liquid filled ibuprofen capsule treated groups respectively.

To read more on this study, click here.

Lipid ibuprofen | Flarin

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to infirst Medical Information via email [email protected] or Tel: +44 (0)808 281 0143

Flarin 200 mg soft capsules contains ibuprofen. Indications: For the relief of rheumatic or muscular pain, pain of non-serious arthritic conditions, backache, neuralgia, migraine, headache, dental pain, dysmenorrhoea, feverishness, symptoms of colds and influenza. Legal category: P. MA authorisation number: PL 51724/0001. RRP: (excl VAT): £9.85 for 30 capsules pack, (excl VAT): £4.76 for 12 capsules pack.

Flarin Joint & Muscular Pain Relief 200 mg soft capsules contains ibuprofen. Indications: For the relief of rheumatic or muscular pain, backache, neuralgia, migraine, headache, dental pain, dysmenorrhoea, feverishness, symptoms of colds and influenza. Legal category: GSL. MA authorisation number: PL 51724/0002. RRP: (excl VAT): £5.79 for 16 capsules pack, RRP: (excl VAT): £4.76 for 12 capsules pack.

MA holder: infirst Limited, Central Point, 45 Beech Street, London, EC2Y 8AD.

Information about these products, including adverse reactions, precautions, contraindications, and method of use can be found at:

https://products.mhra.gov.uk/search/?search=flarin+soft+capsules&page=1&doc=Spc&rerouteType=0

Reference: Bierma-Zeinstra, S.M.A. et al Osteoarthritis and Cartilage, 25 (2017) pp1942-1951.

To verify claims, visit https://hcp.flarin.co.uk/verification/

© 2024 infirst Ltd Privacy Policy Terms & Conditions Cookie Policy IL-WEB 24-001 Date of Preparation: January 2024

Lipid Lock | Flarin